LUNAでは、患者さんにご協力いただいた診療情報をもとに、SLEの診療や治療の向上を目指した研究を行っています。ここでは、その研究成果をご紹介します。
2026年 (7報）
Nakajima T et al.
Serum C-reactive protein levels can predict organ damage in patients with SLE with the lupus low disease activity state.
Lupus. 2026. doi: 10.1177/09612033261473966
Onishi A et al.
Comparison of predictive validity of the Lupus Patient-Reported Outcome and Short-Form-12 for damage accrual in systemic lupus erythematosus.
Rheumatology (Oxford). 2026. doi: 10.1093/rheumatology/keag080
Sagawa R et al.
Disentangling Temporal Factors in Organ Damage Accrual in Systemic Lupus Erythematosus: Onset-Age, Onset-Era, and Aging in the Japanese LUNA Registry
Mod Rheumatol. 2026. doi: 10.1093/mr/roag042
Suzuki N et al.
The relationship between obesity and disease relapse in systemic lupus erythematosus: a retrospective cohort study using the LUNA registry.
Frontiers in Immunology. 2026. doi: 10.3389/fimmu.2026.1781933
Yamaguchi E et al.
The impact of anti-SSA/Ro antibodies on pregnancy outcomes in patients with systemic lupus erythematosus.
Rheumatology (Oxford). 2026. doi: 10.1093/rheumatology/keag122
Sumichika Y et al.
Gender differences in the clinical features and quality of life of Japanese patients with systemic lupus erythematosus: a cross-sectional study based on the LUNA registry.
Arthritis Research & Therapy. 2026. doi: 10.1186/s13075-025-03726-1
Miyake H et al.
Factors and outcomes related to clinical inertia in systemic lupus erythematosus: a multicentre LUNA cohort study.
Rheumatology (Oxford). 2026. doi: 10.1093/rheumatology/keaf504
2025年（3報）
Matsuoka N et al.
Safety of mycophenolate mofetil in systemic lupus erythematosus maintenance therapy: insights from the LUNA registry in a nationwide prospective cohort study.
RMD Open. 2025. doi: 10.1136/rmdopen-2025-005558
Nose Y et al.
Predictive validity of Lupus Patient-Reported Outcome for damage accrual in patients with systemic lupus erythematosus: the LUNA Registry.
Rheumatology (Oxford). 2025. doi: 10.1093/rheumatology/keae341
Sugimoto S et al.
Implications of serum calcitonin gene-related peptide and type I interferon in systemic lupus erythematosus-associated headaches.
Lupus. 2025. doi: 10.1177/09612033251332789
2024年（5報）
Onishi T et al.
Clinical practice pattern of Pneumocystis pneumonia prophylaxis in systemic lupus erythematosus: a cross-sectional study from lupus registry of nationwide institutions (LUNA).
Arthritis Research & Therapy. 2024. doi: 10.1186/s13075-024-03434-2
Takamatsu R et al.
Headache in systemic lupus erythematosus: The LUNA registry cross-sectional study.
Lupus. 2024. doi: 10.1177/09612033241254168
Ichinose K et al.
Evaluating the safety profile of calcineurin inhibitors: cancer risk in patients with systemic lupus erythematosus from the LUNA registry — a historical cohort study.
Arthritis Research & Therapy. 2024. doi: 10.1186/s13075-024-03285-x
Katayama Y et al.
Association between discontinuity of care and patient trust in the usual rheumatologist among patients with systemic lupus erythematosus: a cross-sectional study.
Arthritis Research & Therapy. 2024. doi: 10.1186/s13075-024-03428-0
Sakurai N et al.
Characteristic features of late-onset systemic lupus erythematosus: An observational study of data from the Lupus Registry of Nationwide Institutions.
Lupus. 2024. doi: 10.1177/09612033241281507
2023年（3報）
Hidekawa C et al.
Protective effect of hydroxychloroquine on infections in patients with systemic lupus erythematosus: an observational study using the LUNA registry.
Frontiers in Immunology. 2023. doi: 10.3389/fimmu.2023.1227403
Katayama Y et al.
Association of alcohol consumption and fatigue in SLE: A cross-sectional study from Lupus Registry of Nationwide Institution (LUNA) cohort.
Lupus. 2023. doi: 10.1177/09612033231159471
Yanai R et al.
Number of Attending Physicians and Accumulated Organ Damage in Patients with Systemic Lupus Erythematosus: LUNA Registry Cross-Sectional Study.
Rheumatology and Therapy. 2023. doi: 10.1007/s40744-022-00528-8
2022年（3報）
Hayashi K et al.
Real-world data on vitamin D supplementation and its impacts in systemic lupus erythematosus: Cross-sectional analysis of a lupus registry of nationwide institutions (LUNA).
PLoS One. 2022. doi: 10.1371/journal.pone.0270569
Sada KE et.
Association of one-point glucocorticoid-free status with chronic damage and disease duration in systemic lupus erythematosus: a cross-sectional study.
Lupus Science & Medicine. 2022. doi: 10.1136/lupus-2022-000772
Abe K et al.
Association of low-dose glucocorticoid use and infection occurrence in systemic lupus erythematosus patients: a prospective cohort study.
Arthritis Research & Therapy. 2022. doi: 10.1186/s13075-022-02869-9
2021年（2報）
Saito M et al.
Prevalence and treatment conditions for hypertension and dyslipidaemia complicated with systemic lupus erythematosus: A multi-centre cross-sectional study.
Lupus. 2021. doi: 10.1177/09612033211006790
Miyawaki Y et al.
Association of glucocorticoid doses and emotional health in lupus low disease activity state (LLDAS): a cross-sectional study.
Arthritis Research & Therapy. 2021. doi: 10.1186/s13075-021-02466-2
2020年（2報）
Ohashi K et al.
Risk Factors for Chronic Damage Accumulation Across Different Onset Eras in Systemic Lupus Erythematosus: A Cross-sectional Analysis of a Lupus Registry of Nationwide Institutions (LUNA).
Acta Medica Okayama. 2020. doi: 10.18926/AMO/59949
Morishita M et al.
Damage accrual related to pregnancies before and after diagnosis of systemic lupus erythematosus: a cross-sectional and nested case-control analysis from a lupus registry.
Lupus. 2020. doi: 10.1177/0961203319898766
これらの研究成果は、LUNA研究にご協力いただいた患者さんとご家族のおかげで得られたものです。心より感謝申し上げます。今後も、より良いSLE診療につながる研究を進めてまいります。